A suspicious car accident leaves Joshua and Emma's daughter in a coma. Josh's world unravels when Emma blames him for the accident and then discovers he had an affair with an office colleague. Ostracized from his wife and family and helpless in the face of his daughter's condition, Josh sinks into a deep depression. When Josh begins to receive mysterious signs from his comatose daughter providing clues to the true cause of the accident, is his daughter...

A young doctor at a Boston hospital becomes suspicious when healthy young people undergoing routine operations are mysteriously slipping into irreversible comas.