Robert Neville is the last human survivor in what is left of New York City. A pandemic has left only 1% of the population alive and most of those who survived are no longer human. The infected, now lurking in the shadows, watch Neville's every move. Perhaps mankind's last, best hope, Neville is driven by the only one remaining mission: to find a way to reverse the effects of the virus using his own immune blood.

Susan is a scientist whose research has caused her to neglect virtually everything else in her life, including love. That is until she meets Michael, a talented chef, and suddenly everything starts to change, not just in Susan's life, but in the entire world. While Susan and Michael are experiencing new and unforeseen depths of feeling, all around the globe a new epidemic is causing people to lose their sensory perceptions.