In the 1890's, Detective William Murdoch adopts modern techniques like 'finger marks' and forensics to track Toronto's most sinister killers. Though derided by his skeptical boss, Murdoch finds friends and allies in a lovely pathologist and an eager-to-learn constable. Along the way they cross paths with some of the era's most famous figures, including Nikola Tesla, Arthur Conan Doyle, and Prince Alfred.

Detective William Murdoch uses emerging science such as ballistics and profiling to solve the most dreadful crimes in Victorian-era Toronto.

Joy and heartbreak await Det. William Murdoch and his friends in turn-of-the-century Toronto. After his brutal beating by the dockyard gang, Inspector Brackenreid's future remains uncertain. Constable Crabtree faces life-altering changes, including a new romance, while Dr. Emily Grace and Dr. Julia Ogden join the women's suffrage movement. And in the show's 100th episode, wedding bells ring as Murdoch and Julia finally walk down the aisle.