When Victor's latest creations, an army of engineered killers set loose in modern-day New Orleans, begin to exceed his expectations and exhibit logistical and analytical skills, he plans to eliminate the entire race, a plan that backfires into humankind's ultimate nightmare.

Two years after they saw him die, the man they knew as Victor Helios lives on. Detectives Carson O'Connor and Michael Maddison; Victor's engineered wife, Erika 5, and her companion Jocko; and the original Victor's first creation, the tormented Deucalion, have all arrived at a small Montana town where their old alliance will be renewed--and tested--by forces from within and without, and where the dangers they face will eclipse any they have yet encountered....

Searching in Los Angeles for the descendant of the man whose right eye was used to create his dad, J.D. discovers that the man, Sam Hammer, is a detective on the trail of a werewolf--and finds himself arrested at the request of Frankenstein's daughter.

Prodigal son - Tough New Orleans detective Carson O'Connor and her partner, Michael Maddison, investigate a string of murders, unaware that the culprit they seek was created by Victor Frankenstein, who has survived two hundred years and is populating the city with a new race of "perfect" beings, and that his original creation, Deucalion, is hunting his maker. City of night - Not even Victor Helios -- once Frankenstein -- can stop the engineered killers...