Stink Moody, friends Webster and Sophie, and Mrs. Birdwistle visit tourist attractions in Virginia as they try to give away 101 guinea pigs rescued from a laboratory, although Stink is very reluctant to relinquish his favorite, Astro.

"The laughs continue when Fido, the guinea pig that thinks she's a dog, has a pup that thinks she's a squirrel. A sequel to Guinea Dog"--

Sam chooses a guinea pig named Henry to be her pet, envisions a dog named Nelly visiting and helping her younger brother Liam feel comfortable in his kindergarten class, and encourages Liam to also get a guinea pig as a pet.

Harry feels ignored when his family pays attention to the neighbor's visiting guinea pig, but everything changes when the children bring both Harry and the guinea pig to school.

When Weenie the weiner dog, who loves meat loaf, cannot resist the one on the counter top that belongs to Bob, his human, he and Bob's other pets, Frank the cat and Beans the guinea pig, join forces to come up with a replacement.

When Ms. Day's class takes a field trip to an apple orchard, Fluffy the guinea pig goes along, but will he ever get to eat his apple?

Jack Frost steals Georgia the Guinea Pig Fairy's pet and Rachel and Kirsty set out to rescue him.

Groundhog Dog inspires the class to celebrate Groundpig Day with their guinea pig Fluffy, and Fluffy gets to help an unhappy groundhog.

As Christmas nears, Amy and her friends in the Critter Club try to find a home for two adorable guinea pigs.