Beginning with a prologue in which a young Indiana Jones is introduced, the epic continues with the adult Indy embarking on a perilous quest for his father, Professor Henry Jones, Sr. The Nazis are on the trail of the Holy Grail, and have kidnapped the professor, who is an authority on the Cup of Christ. Indy inches through rat-filled catacombs, battles Nazis in biplane dogfights, and braves the firepower of unstoppable tanks.

Indy tries to outrace a brilliant and beautiful agent for the mystical, all-powerful Crystal Skull of Akator. Teaming up with a rebellious young biker and his spirited love Marion, Indy takes you on a breathtaking, action-packed adventure.

After barely escaping a Shanghai nightclub brawl, Indiana Jones crash-lands into the wilds of India where he uncovers a scheme that has enslaved a remote village's children. Indy must save the children and avoid becoming a slave himself to the evil Thuggee cult.