After meeting at a psychiatric hospital, damaged souls Jane and Joey change their lives with a road trip after receiving a letter from the son she gave up for adoption years ago. Along the way they encounter colorful people and magical revelations that will changes their lives.

When young doctor Edward Newgate arrives at Stonehearst Asylum in search of an apprenticeship, he is warmly welcomed by Superintendent Dr. Lamb and a mesmerizing woman by the name of Eliza Grave. Edward is intrigued by Lamb's modern methods of treating the insane until a series of unusual events leads him to make a horrifying discovery, exposing Lamb's utopia and pushing Edward to the limits of his conscience.

When U.S. Marshall Teddy Daniels arrives at the asylum for the criminally insane on Shutter Island, what starts as a routine investigation quickly takes a sinister turn. As the investigation unfolds and Daniels uncovers more shocking and terrifying truths about the island, he also learns there are some places that never let you go.