When a woman and her son mysteriously vanish, FBI agent Daria Francis is dispatched to the small town of Devil's Gate, North Dakota to investigate the number one suspect: religious fanatic Jackson Pritchard, husband and father of the missing persons. However, when Francis and local deputy Colt arrive at Pritchard's foreboding property, they discover much more than they bargained for lurking in the basement.

A young woman named Sophie is cursed by the Witch of the Waste and is turned into an old woman who is unable to tell anyone of her plight. Unable to continue her job at her mother's hat shop, she goes to the ambulatory castle of the notorious wizard Howl and insinuates herself into his household. Sophie befriends Calcifer, the fire demon who powers the castle and who is bound to Howl by a contract, the terms of which Calcifer cannot reveal. They promise...

While investigating a series of deadly labor accidents at Tokyo Bay, police detectives Kusumi and Hata stumble onto a government conspiracy involving a deadly biological weapon, WXIII: The Wasted Thirteen. Can they stop it before it's too late?