When a snake spirit suffers from memory loss after living in human disguise for too long, she enters an unlikely romance with a handsome snake hunter.

Veterinary scientist Mark Evans and comparative anatomist Joy Reidenberg team up with local "python hunters" in the Florida Everglades, as they work to control the population of the invasive Burmese python, which have been thriving and threating other native animal species populations in the region, and dissect and examine the anatomy of a python.

Nelville Flynn is escorting a witness on a plane that is bound for Los Angeles. The problem is that an assassin is bent on killing the witness. The assassin releases a crate containing about 450 deadly snakes onto the same plane. Nelville finds out and he becomes bent on doing his job and getting the snakes back where they belong - on land. If the snakes won't cooperate with Nelville, he will just have to send the snakes on to snake heaven.