A doctor who is deathly afraid of spiders moves his family to a small town where the disgusting arachnids are attacking the townspeople. He must overcome his fear to save the community, but it may already be too late!

In ordinary Somerset County, a young farm girl named Fern rescues the runt of a litter of pigs from her father's ax. Fern names the pig Wilbur, takes care of him, and continues to visit him every day after he is moved to her Uncle Homer Zuckerman's barn across the road. But it's Wilbur's friendship with Charlotte the spider that ultimately saves him from the "smoke house" when Charlotte's talent for weaving praiseworthy words about Wilbur into her...