In Season Five of the Handmaid's Tale, June faces consequences for killing Commander Waterford while struggling to redefine her identity and purpose. The widowed Serena attempts to raise her profile in Toronto as Gilead's influence creeps into Canada. Commander Lawrence works with Nick and Aunt Lydia as he tries to reform Gilead and rise to power. June, Lucke, and Moira fight Gilead from a distance as they continue their mission to save and reunite...

In Season Four, June strikes back against Gilead as a fierce rebel leader, but the risks she takes bring dangerous new challenges, and her quest for justice and revenge threatens to consume her.

A religion-based autocracy has taken over most of the United States, renaming the country Gilead. In this country women are second-class citizens. Anyone trying to escape is punished. One such person is June, who is captured while trying to escape with her husband and child and is sentenced to be a handmaid, bearing children for childless government officials. As a handmaid, June is renamed Offred.

Awakening in the form of a warrior from the time when the Earth was lost to a powerful alien race, cybernetic avatar Merlyn Athrawes assists the island empire of Charis to gain independence from the controlling Church that has forbidden technology and human development.